Interferon induction of fibroblast proteins with guanylate binding activity.
作者： Y S Cheng , R J Colonno , F H Yin
DOI: 10.1016/S0021-9258(18)32242-7
关键词: Cell culture 、 Biochemistry 、 Guanylate-binding protein 、 GTP-binding protein regulators 、 Isoelectric point 、 Messenger RNA 、 DNA-binding protein 、 Biology 、 Interferon 、 Fibroblast
摘要: Treatment of human diploid fibroblastic cells with interferon induces the synthesis two guanylate binding proteins (GBP) molecular weights 67,000 and 56,000. The Mr = protein (67K GBP) is synthesized upon treatment either alpha-, beta-, or gamma-interferon. Among these interferons, gamma-interferon a higher level 67K GBP synthesis. in beta- gamma-interferon-treated has charge forms isoelectric points 6.0 5.8, respectively. 56,000 induced by using alpha- beta-interferon, but its undetectable. amounts radioactive GBPs fibroblasts are proportional to purified beta-interferon used for inductions. Syntheses require transcription cellular genes because their syntheses completely blocked actinomycin D treatments. mRNA found that treated gamma-interferon, it not detected untreated cells. More accumulated than beta-interferon-treated fibroblasts. This consistent more
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