Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice.
作者： P Staeheli , P Dreiding , O Haller , J Lindenmann
DOI: 10.1016/S0021-9258(18)89666-1
关键词:
摘要: Interferon-alpha/beta induces in cells from mice carrying the influenza virus resistance allele Mx+ synthesis of a unique 75,000-dalton protein (designated here Mx) that was not detectable interferon-treated Mx- lacking (Horisberger, M. A., Staeheli, P., and Haller, O. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 1910-1914). We have immunized BALB/c with extracts congenic BALB X A2G-Mx mice. Resulting hyperimmune sera immunoprecipitated single interferon-inducible embryo cells. Sera did react any Synthesis immunoprecipitable Mx induced by interferon-alpha/beta but interferon-gamma diverse genetic backgrounds. Monoclonal antibodies to were selected similar immunoprecipitation assays. One discrete vitro translation product relevant mRNA reacted polyclonal monoclonal indistinguishable vivo synthesized Mx.
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