Extra-column dead volume in simulated moving bed separations: theory and experiments.

摘要: Abstract In small-scale SMB units typically set up by a number of HPLC columns connected in series, the volume connecting tubing parts and valves may become comparable to column volume. Therefore, guarantee proper satisfying separation results, introduced extra-column dead needs be considered calculations operating parameters. this work, impact on performance is studied, with objective introduce guidelines rather simple rules account for it. It shown, how these results can used frame triangle theory determine conditions that allow achieve desired performance. For experiments racemic mixture ( ± )-3,5-bis[1-(4-methoxyphenyl)-1-methyl]hepta-3,4-diene-1,6-diyne was carried out. The numerical model simulation describes explicitly geometric configuration HPLC–SMB laboratory unit take into effect