The Role of the Local Immune Response in the Pathogenesis of Peptic Ulcer Formation

摘要: Mucosal immune responses are designed to provide local protection against infection, without inducing excessive amounts of inflammation that would alter epithelial integrity or function. It has become clear the epithelium not only serves as a barrier exclude pathogens, but also initiates host infection. Gastric cells infected with Helicobacter pylori can respond within hours produce inflammatory mediators recruit and activate neutrophils. The gastric be recognized by T-cells. resulting in their activation ability induce damage. During infection H. pylori, there is remarkable increase level IgG antibodies, which may recognize damage epithelium. Thus, activated neutrophils, T-cells auto-antibodies contribute weakened allows luminal acid other factors peptic ulceration. appears play key role initiation t...