Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography

作者: Espen Rusten , Bernt Louni Rekstad , Christine Undseth , Ghazwan Al-Haidari , Bettina Hanekamp

DOI: 10.1186/S13014-017-0883-Z

关键词: Positron emission tomographyRadiologyMedicineChemoradiotherapyNuclear medicinePreclinical imagingSørensen–Dice coefficientMagnetic resonance imagingAnal cancerMedical imagingRadiation therapy

摘要: To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer inter-modality variability. Nineteen patients undergoing chemoradiotherapy were prospectively included. Planning computed (CT) images co-registered 18F–fluorodexocyglucose (FDG) PET/CT T2 diffusion weighted (DW) MR images. Three oncologists delineated the Gross Tumor Volume (GTV) according national guidelines visible tumor tissue (GTVT). MRI PET based delineations evaluated by absolute volumes Dice similarity coefficients. The median GTVs was 27 31 cm3 for MRI, respectively, while it 6 11 cm3 GTVT. Both GTV GTVT highly correlated between delineators (r = 0.90 r = 0.96, respectively). coefficient 0.75 when comparing on (GTVPET) CT (GTVMRI). 0.56 (GTVT_PET) same (GTVT_MRI). Margins 1–2 mm in axial plane 7–8 mm superoinferior direction required coverage individual observer’s GTVs. rather good agreement PET- MRI-based indicates that either modality may be used standard cancer. However, larger deviations found GTVT, which impact future boost strategies.

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