作者: Espen Rusten , Bernt Louni Rekstad , Christine Undseth , Ghazwan Al-Haidari , Bettina Hanekamp
DOI: 10.1186/S13014-017-0883-Z
关键词: Positron emission tomography 、 Radiology 、 Medicine 、 Chemoradiotherapy 、 Nuclear medicine 、 Preclinical imaging 、 Sørensen–Dice coefficient 、 Magnetic resonance imaging 、 Anal cancer 、 Medical imaging 、 Radiation therapy
摘要: To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer inter-modality variability. Nineteen patients undergoing chemoradiotherapy were prospectively included. Planning computed (CT) images co-registered 18F–fluorodexocyglucose (FDG) PET/CT T2 diffusion weighted (DW) MR images. Three oncologists delineated the Gross Tumor Volume (GTV) according national guidelines visible tumor tissue (GTVT). MRI PET based delineations evaluated by absolute volumes Dice similarity coefficients. The median GTVs was 27 31 cm3 for MRI, respectively, while it 6 11 cm3 GTVT. Both GTV GTVT highly correlated between delineators (r = 0.90 r = 0.96, respectively). coefficient 0.75 when comparing on (GTVPET) CT (GTVMRI). 0.56 (GTVT_PET) same (GTVT_MRI). Margins 1–2 mm in axial plane 7–8 mm superoinferior direction required coverage individual observer’s GTVs. rather good agreement PET- MRI-based indicates that either modality may be used standard cancer. However, larger deviations found GTVT, which impact future boost strategies.