The organization of the endocrine pancreas: a hypothetical unifying view of the phylogenetic differences.

摘要: Abstract The comparative morphology of the endocrine pancreas is seemingly quite divergent in vertebrate classes bony fish, amphibians, reptiles, birds, and mammals. However, a hypothesis based on concept regional differences islets unifies this apparent diversity. Such has several elements: (1) splenic portion larger concentration islet tissue than most other parts pancreas; (2) portions are contain A, B, D cells but only few or no PP cells; (3) duodenal smaller principally B with numerous occasional A cells. In an often limited area found greater number elsewhere usually as major component islets. This organization may have functional significance not be just embryological pattern. Higher nonmammalian vertebrates readily encompassed by mammals included well. These concepts important implications for our understanding mammalian pancreas.