Genomics in Pathogenesis of Cirrhosis

摘要: Publisher Summary Cirrhosis is the pathogenic hallmark of advanced liver injury. It morphologically defined by distortion hepatic architecture dense bands fibrosis “scar” leading to nodules hepatocytes. The causes cirrhosis are varied with many etiologies. development a premalignant condition, virtually all cases cancer developing in individuals prior cirrhosis. Various intrahepatic cell populations essential understanding pivotal involved and stellate cell. However, functional unit hepatocyte, which type from hepatocellular carcinoma (HCC) develops. This chapter discusses mechanisms context this process evolves. Genomic medicine promises new insights into pathogenesis hope individualized predictive aiming prevent sequelae failure HCC. identification genetic loci associated progressive injury has focused on underlying disease rather than common pathway eventual