No effect of teriparatide on migration in total knee replacement

摘要: Background and purpose — Aseptic loosening is a main cause of late revision in total knee replacement (TKR). Teriparatide, recombinant parathyroid hormone (PTH), stimulates osteoblasts has been suggested to improve cancellous bone healing humans. This might also be relevant for prosthesis fixation. We used radiostereometric analysis (RSA) investigate whether teriparatide influences Early migration as measured by RSA can predict future loosening.Patients methods In randomized controlled trial with blind evaluation, 50 patients osteoarthritis the were allocated treatment group (Forsteo, 20 μg daily 2 months postoperatively) or an untreated control group. was performed postoperatively at 6 months, 12 24 months. The primary effect variable maximal point motion (MTPM) from months.Results Median similar groups (teriparatide: 0.14 mm,...