Effect of inhibiting prostaglandin synthesis in pregnant sheep with 4-aminoantipyrine under normothermic and hyperthermic conditions.

摘要: Infusion of the prostaglandin synthetase inhibitor 4-aminoantipyrine at a rate 20 mg/min via fetal tarsal vein during normothermic conditions (ambient temperatures=24° C) significantly decreased concentrations prostaglandins E 2 and F 2α in maternal arterial plasma uterine umbilical plasma. The infusion was associated with small but significant rise temperature fall pH. Respiratory alkalosis developed fetuses hyperthermia by raising ambient to 43° C for 8 hours. In contrast, produced metabolic acidosis as indicated pH an increase Paco , even though ewe remained hypocapnic. Four 10 died or shortly after hyperthermia. These results indicate that uteroplacental synthesis is essential allow fetus adapt body suggests inhibitors should be used caution pregnancy.