Antipsychotic drugs block LSD-induced disaggregation of brain polysomes
作者： Larry Holbrook , Ian Brown
DOI: 10.1016/0024-3205(77)90272-7
关键词: Phentolamine 、 Pentobarbital 、 Polysome 、 Chemistry 、 Pizotyline 、 Pharmacology 、 Neurotransmitter receptor 、 Chlorpromazine 、 Propranolol 、 Haloperidol 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Abstract Intravenous injection of LSD at 10, 25 and 100 μg/kg to young rabbits induces brain specific disaggregation polysomes monosomes. Polysomes in the cerebral hemispheres, cerebellum remaining stem are affected. Neurotransmitter receptors involved since prior receptor blockers haloperidol, chlorpromazine, propranolol, phentolamine, or pizotyline prevent drug-induced polysome shift. Depression neuronal activity with sedative levels ethanol pentobarbital also eliminates disaggregation.
elsevier.com
sci-hub.se 参考文章(16)
Ernest L. Abel, Drugs and behavior: A primer in neuropsychopharmacology ,(1974)
G. K. Aghajanian, W. E. Foote, M. H. Sheard, Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Science. ,vol. 161, pp. 706- 708 ,(1968) , 10.1126/SCIENCE.161.3842.706
Kern Von Hungen, Sidney Roberts, Diane F. Hill, Interactions between lysergic acid diethylamide and dopamine-sensitive adenylate cyclase systems in rat brain. Brain Research. ,vol. 94, pp. 57- 66 ,(1975) , 10.1016/0006-8993(75)90876-8
Theodore W. Rall, On the importance of cyclic AMP in neurobiology: An essay Metabolism. ,vol. 24, pp. 241- 248 ,(1975) , 10.1016/0026-0495(75)90105-5
B. F. Weiss, J. L. Liebschutz, R. J. Wurtman, H. N. Munro, PARTICIPATION OF DOPAMINE- AND SEROTONIN-RECEPTORS IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l-DOPA AND l-5-HTP Journal of Neurochemistry. ,vol. 24, pp. 1191- 1195 ,(1975) , 10.1111/J.1471-4159.1975.TB03897.X
Gilles Fillion, Marie-Paule Fillion, Christina Spirakis, Jean-Marie Bahers, Joseph Jacob, 5-Hydroxytryptamine binding to synaptic membranes from rat brain. Life Sciences. ,vol. 18, pp. 65- 74 ,(1976) , 10.1016/0024-3205(76)90275-7
P.F. Spano, K. Kumakura, G.C. Tonon, S. Govoni, M. Trabucchi, LSD and dopamine-sensitive adenylate-cyclase in various rat brain areas. Brain Research. ,vol. 93, pp. 164- 167 ,(1975) , 10.1016/0006-8993(75)90296-6
James R. Couch, Action of LSD on raphe neurons and effect on presumed serotonergic raphe synapses Brain Research. ,vol. 110, pp. 417- 424 ,(1976) , 10.1016/0006-8993(76)90419-4
James L. Bennett, George K. Aghajanian, D-LSD binding to brain homogenates: Possible relationship to serotonin receptors Life Sciences. ,vol. 15, pp. 1935- 1944 ,(1974) , 10.1016/0024-3205(74)90044-7
Rex Y. Wang, George K. Aghajanian, Inhibition of neurons in the amygdala by dorsal raphe stimulation: Mediation through a direct serotonergic pathway Brain Research. ,vol. 120, pp. 85- 102 ,(1977) , 10.1016/0006-8993(77)90499-1