Hippo Pathway and Apoptosis
作者： Garth Hamilton , Eric O’Neill
DOI: 10.1007/978-1-4614-6220-0_7
关键词: Cell biology 、 Kinase 、 Biology 、 Inhibitor of apoptosis 、 Transcription (biology) 、 Transcription factor 、 Histone 、 Genetic screen 、 Hippo signaling pathway 、 MST1 、 Bioinformatics
摘要: The Hippo pathway is an established that regulates apoptosis. earliest characterisations of the mammalian MST1/2 kinases indicated they were potent inducers apoptosis in response to a wide range stimuli. Elucidation components via genetic screens Drosophila revealed signalling through required for induction during development. Central control developmental regulation transcriptional co-activator Yki, whose interaction with transcription factors including Sd, Mad and Tsh/Hth drives apoptotic inhibitors Diap-1 microRNA Bantam. In mammals it clear core MST1/2-LATS1/2 kinase cassette has various downstream which lead pro-apoptotic target genes multiple factors, caspase activation histone modification. LATS1/2 Yap function complex network p53 its associated regulatory proteins from ASPP family which, association Yap, can have opposing effects on While important inhibitor subject similar also promotes p73. Evidence suggests tumour suppressor RASSF1A determinant mediating activities factor interactions.
springer.com
sci-hub.se 参考文章(171)
E. L. Greer, A. Brunet, FOXO transcription factors in ageing and cancer. Acta Physiologica. ,vol. 192, pp. 19- 28 ,(2007) , 10.1111/J.1748-1716.2007.01780.X
Xavier Espanel, Marius Sudol, Yes-associated Protein and p53-binding Protein-2 Interact through Their WW and SH3 Domains Journal of Biological Chemistry. ,vol. 276, pp. 14514- 14523 ,(2001) , 10.1074/JBC.M008568200
Binnaz Kucuk Staley, Kenneth D. Irvine, Hippo signaling in Drosophila: recent advances and insights. Developmental Dynamics. ,vol. 241, pp. 3- 15 ,(2012) , 10.1002/DVDY.22723
Hideaki Kakeya, Rie Onose, Hiroyuki Osada, Caspase-mediated Activation of a 36-kDa Myelin Basic Protein Kinase during Anticancer Drug-induced Apoptosis Cancer Research. ,vol. 58, pp. 4888- 4894 ,(1998)
Tian Xu, R. A. Stewart, Wan Yu, Waiyi Wang, Sheng Zhang, Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase Development. ,vol. 121, pp. 1053- 1063 ,(1995) , 10.1242/DEV.121.4.1053
Arnaud M Vigneron, Karen H Vousden, An indirect role for ASPP1 in limiting p53‐dependent p21 expression and cellular senescence The EMBO Journal. ,vol. 31, pp. 471- 480 ,(2012) , 10.1038/EMBOJ.2011.402
Louise van der Weyden, Angelos Papaspyropoulos, George Poulogiannis, Alistair G. Rust, Mamunur Rashid, David J. Adams, Mark J. Arends, Eric O'Neill, Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis Cancer Research. ,vol. 72, pp. 3817- 3827 ,(2012) , 10.1158/0008-5472.CAN-11-3343
Dawang Zhou, Claudius Conrad, Fan Xia, Ji-Sun Park, Bernhard Payer, Yi Yin, Gregory Y. Lauwers, Wolfgang Thasler, Jeannie T. Lee, Joseph Avruch, Nabeel Bardeesy, Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene Cancer Cell. ,vol. 16, pp. 425- 438 ,(2009) , 10.1016/J.CCR.2009.09.026
Sung-Hee Ahn, Wang L. Cheung, Jer-Yuan Hsu, Robert L. Diaz, M.Mitchell Smith, C.David Allis, Sterile 20 Kinase Phosphorylates Histone H2B at Serine 10 during Hydrogen Peroxide-Induced Apoptosis in S. cerevisiae Cell. ,vol. 120, pp. 25- 36 ,(2005) , 10.1016/J.CELL.2004.11.016
Alfred A. Reszka, Judit M. Halasy-Nagy, Patricia J. Masarachia, Gideon A. Rodan, Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis Journal of Biological Chemistry. ,vol. 274, pp. 34967- 34973 ,(1999) , 10.1074/JBC.274.49.34967