Early weight-loss success identifies nonresponders after a lifestyle intervention in a worksite diabetes prevention trial.

摘要: Abstract Background People with prediabetes are at increased risk for developing type 2 diabetes mellitus. Weight reduction through lifestyle modification can significantly reduce risk. Yet, weight loss varies among individuals and some people do not achieve clinically meaningful after treatment. Objective Our aim was to evaluate the time point threshold achieving ≥5% completion of a 16-week worksite, intervention prevention. Design change before behavioral participants randomized experimental group examined. Participants/setting Individuals aged 18 65 years body mass index (calculated as kg/m ) 25 50 Ohio State University were eligible. Intervention The 16-week, group-based intervention, adapted from Diabetes Prevention Program, delivered 32 in group. Main outcome measures Percent assessed weekly during 4- 7-month follow-up. Statistical analyses performed Linear regression modeled relationship between percent month 1 4 7 months. Logistic failure lose months using first intervention. Results week 5 associated (all P Conclusions treatment is critical period helping loss. Otherwise, who fail least 2.5% may benefit more intensive rescue efforts or stepped-care interventions.