Regiospecific introduction of alkyl groups into 4-position of pyridine novel synthesis of 4-substituted pyridines
作者： Kin-ya Akiba , Hideto Matsuoka , Makoto Wada
DOI: 10.1016/S0040-4039(01)82074-8
关键词: Pyridine 、 Medicinal chemistry 、 Alkylation 、 Butyllithium 、 Phosphonate 、 Chemistry 、 Alkyl 、 Organic chemistry
摘要: Abstract Regiospecific synthesis of 4-substituted pyridines is attained via alkylation diisopropyl 1-ethoxycarbonyl-1, 4-dihydropyridine-4-phosphonate followed by treatment with butyllithium. The phosphonate prepared directly from pyridine in one pot.
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