Synthesis of anti and syn hydroxy-iso-evoninic acids.
作者： Sarah A. Warren , Stephen Stokes , Christopher S. Frampton , Andrew J. P. White , Alan C. Spivey
DOI: 10.1039/C2OB25625H
关键词:
摘要: The first synthesis of hydroxy-iso-evoninic acid (2), a pyridyl diacid found as macrodilactone bridging ligand in bioactive Celastraceae sesquiterpenoid-based natural products, has been achieved 9 steps and an overall yield 26%. utilizes benzilic ester rearrangement (BER) late stage benzylic oxidation to give access all four stereoisomers whose absolute stereochemistry was assigned following chromatographic separation anomalous dispersion X-ray crystallography.
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