Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure

摘要: Maintenance of cardiac structure and Z-disc signaling are key factors responsible for protecting the heart in a setting stress, but how these processes regulated is not well defined. We recently demonstrated that PI3K(p110α) protects against myocardial infarction. The aim this study was to determine whether directly regulates components structure. To address question, unique three-dimensional virtual muscle model applied gene expression data from transgenic mice with increased or decreased activity under basal conditions (sham) infarction display location structural proteins. Key findings analysis were then validated experimentally. visually highlighted reciprocally transcripts associated PI3K activation encoded costamere, including melusin. Studies performed assess melusin interact heart. Here, we identify novel melusin-PI3K interaction generates lipid kinase activity. direct impact on myocyte assessed by treating neonatal rat ventricular myocytes inhibitors examining myofiber morphology hearts mice. Results demonstrate critical maturation alignment. In summary, genes essential signaling, interacts melusin,