Filamins in cell signaling, transcription and organ development.
作者： Alex-Xianghua Zhou , John H. Hartwig , Levent M. Akyürek
DOI: 10.1016/J.TCB.2009.12.001
关键词:
摘要: Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin filament networks and link them to cellular membranes where they integrate cell architectural signaling functions important for locomotion. have been shown bind with diverse implicated in human genetic diseases including malformations of the skeleton, brain, heart. Mouse models filamin deficiency advanced our understanding roles filamins play embryonic development disease progression. These studies provide clear evidence cytoskeletal signaling, transcription organ development. This review focuses on emerging transcription, emphasis motility
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sci-hub.se 参考文章(84)
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