Overexpression of CIAPIN1 inhibited pancreatic cancer cell proliferation and was associated with good prognosis in pancreatic cancer.

摘要: Cytokine-induced antiapoptotic molecule (CIAPIN1), a newly identified apoptosis inhibitor, has been found to participate in the process of proliferation and tumorigenicity for several cancers. The aim this study was evaluate prognostic value CIAPIN1 pancreatic cancer probe its function carcinogenesis. We that protein absent or reduced cell lines. There also loss decrease expression 118 cases tissues as compared with 82 normal tissues. In Cox proportional hazards model, independently predicted better survival (P<0.0001). Adenoviral-mediated restoration greatly repressed vitro suppressed Balb/c nude mice. Our data revealed inhibition cells by enforcing at least partly through delaying cycle progression inducing apoptosis. summary, our work novel CIAPIN1, which might possibly be used an independent factor potential therapeutic target cancer.