Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema.

作者: Kota Ishizawa , Hiroshi Kubo , Mitsuhiro Yamada , Seiichi Kobayashi , Muneo Numasaki

DOI: 10.1016/S0014-5793(03)01399-1

关键词: Bone marrowImmunologyElastaseLungGranulocyteBiologyCellular differentiationProgenitor cellGranulocyte colony-stimulating factorRegeneration (biology)Cancer research

摘要: All-trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, origin progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be source for several cell types. Mice with elastase-induced emphysema were treated ATRA, granulocyte colony-stimulating factor (G-CSF), or a combination both. ATRA G-CSF promoted increased marrow-derived (BMC) numbers alveoli. Combined treatment both had an additive effect, which indicated BMC mobilization might important regeneration.

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