Coupling of phospholipase C and PI3K/PTEN signaling pathways in Physarum polycephalum : The action of U73122 on motile and autooscillatory activity of plasmodium
作者： N. B. Matveeva , V. A. Teplov , S. I. Beylina
DOI: 10.1134/S1990747812030142
关键词: PI3K/AKT/mTOR pathway 、 LY294002 、 Chemotaxis 、 Phospholipase C 、 Cell biology 、 Motility 、 Biology 、 Physarum polycephalum 、 Signal transduction 、 Wortmannin
摘要: The possibility of tight coupling phospholipase C with the signal pathway PI3K/ PTEN, a ubiquitous mechanism for control chemotaxis and cell shape in free-living amoebae mammalian tissue cells, has been investigated Physarum polycephalum plasmodium, multinuclear amoeboid autooscillatory mode motility. It was found that on maintenance contractile autooscillations protoplasmic shuttle streaming, U73122, an inhibitor transduction to C, induces degradation plasmodium frontal zone, decreases efficiency locomotion suppresses toward glucose as well response oscillator this attractant. identity effects U73122 those shown wortmannin LY294002, widely used PI3K inhibitors (Matveeva et al. 2008. Biophysics. 53, 533–538), suggests pathways PI3K/PTEN. increases period oscillations abolishes its cyclic changes attributed migration. results indicate motile behavior is under receptor-mediated control.
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