Pharmacogenetics of anti-cancer drugs: State of the art and implementation - recommendations of the French National Network of Pharmacogenetics.
作者： Sylvie Quaranta , Fabienne Thomas
DOI: 10.1016/J.THERAP.2017.01.005
关键词: Irinotecan 、 Pharmacology 、 Thiopurine methyltransferase 、 Pharmacogenetics 、 Capecitabine 、 Medicine 、 Cancer 、 Dihydropyrimidine dehydrogenase 、 DPYD 、 Evidence-based medicine 、 Intensive care medicine
摘要: Individualized treatment is of special importance in oncology because the drugs used for chemotherapy have a very narrow therapeutic index. Pharmacogenetics may contribute substantially to clinical routine optimizing cancer limit toxic effects while maintaining efficacy. This review presents usefulness pharmacogenetic tests some key applications: dihydropyrimidine dehydrogenase (DPYD) genotyping fluoropyrimidine (5-fluorouracil, capecitabine), UDP glucuronosylstransferase (UGT1A1) irinotecan and thiopurine S-methyltransferase (TPMT) drugs. Depending on level evidence, French National Network (RNPGx) has issued three levels recommendations these tests: essential, advisable, potentially useful. Other applications, which evidence still discussed, will be evoked final section this review.
sci-hub.se 参考文章(63)
Laura Dean, Irinotecan Therapy and UGT1A1 Genotype National Center for Biotechnology Information (US). ,(2015)
Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi, Fabienne Thomas, Sylvie Quaranta, Nicolas Picard, Marie-Anne Loriot, Delphine Poncet, Marie-Claude Gagnieu, Cécile Ged, Franck Broly, Valérie Le Morvan, Régis Bouquié, Marie-Pierre Gaub, Laurent Philibert, François Ghiringhelli, Chantal Le Guellec, Intérêt du génotypage de l’UGT1A1 dans le cadre du traitement des cancers digestifs par irinotécan Bulletin Du Cancer. ,vol. 101, pp. 533- 553 ,(2014) , 10.1684/BDC.2014.1933
Didier Meulendijks, Linda M Henricks, Gabe S Sonke, Maarten J Deenen, Tanja K Froehlich, Ursula Amstutz, Carlo R Largiadèr, Barbara A Jennings, Anthony M Marinaki, Jeremy D Sanderson, Zdenek Kleibl, Petra Kleiblova, Matthias Schwab, Ulrich M Zanger, Claire Palles, Ian Tomlinson, Eva Gross, André B P van Kuilenburg, Cornelis J A Punt, Miriam Koopman, Jos H Beijnen, Annemieke Cats, Jan H M Schellens, Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data Lancet Oncology. ,vol. 16, pp. 1639- 1650 ,(2015) , 10.1016/S1470-2045(15)00286-7
M C Etienne, J L Lagrange, O Dassonville, R Fleming, A Thyss, N Renée, M Schneider, F Demard, G Milano, Population study of dihydropyrimidine dehydrogenase in cancer patients. Journal of Clinical Oncology. ,vol. 12, pp. 2248- 2253 ,(1994) , 10.1200/JCO.1994.12.11.2248
Linda M Henricks, Carin ATC Lunenburg, Didier Meulendijks, Hans Gelderblom, Annemieke Cats, Jesse J Swen, Jan HM Schellens, Henk-Jan Guchelaar, Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score Pharmacogenomics. ,vol. 16, pp. 1277- 1286 ,(2015) , 10.2217/PGS.15.70
Adam M. Lee, Qian Shi, Emily Pavey, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope, Jeffrey L. Berenberg, Richard M. Goldberg, Robert B. Diasio, DPYD Variants as Predictors of 5-fluorouracil Toxicity in Adjuvant Colon Cancer Treatment (NCCTG N0147) Journal of the National Cancer Institute. ,vol. 106, ,(2014) , 10.1093/JNCI/DJU298
X Liu, D Cheng, Q Kuang, G Liu, W Xu, None, Association of UGT1A1*28 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians Pharmacogenomics Journal. ,vol. 14, pp. 120- 129 ,(2014) , 10.1038/TPJ.2013.10
Marie-Christine Etienne-Grimaldi, Jean-Christophe Boyer, Fabienne Thomas, Sylvie Quaranta, Nicolas Picard, Marie-Anne Loriot, Céline Narjoz, Delphine Poncet, Marie-Claude Gagnieu, Cécile Ged, Franck Broly, Valérie Le Morvan, Régis Bouquié, Marie-Pierre Gaub, Laurent Philibert, François Ghiringhelli, Chantal Le Guellec, , UGT1A1 genotype and irinotecan therapy: general review and implementation in routine practice Fundamental & Clinical Pharmacology. ,vol. 29, pp. 219- 237 ,(2015) , 10.1111/FCP.12117
Johanna Sistonen, Barbara Büchel, Tanja K Froehlich, Dominic Kummer, Stefano Fontana, Markus Joerger, André BP van Kuilenburg, Carlo R Largiadèr, Predicting 5-fluorouracil toxicity: DPD genotype and 5,6-dihydrouracil:uracil ratio Pharmacogenomics. ,vol. 15, pp. 1653- 1666 ,(2014) , 10.2217/PGS.14.126
Zhe-Yi Hu, Qi Yu, Qi Pei, Cheng Guo, Dose-Dependent Association between UGT1A1*28 Genotype and Irinotecan-Induced Neutropenia: Low Doses Also Increase Risk Clinical Cancer Research. ,vol. 16, pp. 3832- 3842 ,(2010) , 10.1158/1078-0432.CCR-10-1122