Dose-Dependent Association between UGT1A1*28 Genotype and Irinotecan-Induced Neutropenia: Low Doses Also Increase Risk
作者： Zhe-Yi Hu , Qi Yu , Qi Pei , Cheng Guo
DOI: 10.1158/1078-0432.CCR-10-1122
关键词:
摘要: Purpose: A previous meta-analysis showed that the association between UGT1A1*28 genotype and irinotecan-induced neutropenia was influenced by irinotecan dose risk of similar at low doses for patients with all genotypes. However, sample sizes low- high-dose groups were small. Because additional studies have now been reported, an updated refined is needed. Experimental Design: Meta-analyses done to assess relationship neutropenia. The relative extent glucuronidation (REG) SN-38 also examined. included stratified into different groups. Results: total 1,998 analysis 581 REG. significantly higher among a UGT1A1*28/*28 than those carrying UGT1A1*1 allele(s) [relative (RR), 2.43; 95% confidence interval, 1.34-4.39; P = 0.003]. In addition, RR comparable medium (2.43 versus 2.00). high (7.22 2.04). We found weighted mean difference REG (UGT1A1*1/*1 or UGT1A1*1/*28 UGT1A1*28/*28) increased increasing irinotecan. Conclusions: conclusion, associated not only but doses. dose-dependent manner explained why dependent. Clin Cancer Res; 16(15); 3832–42. ©2010 AACR.
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sci-hub.se 参考文章(37)
Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo, Estimating the mean and variance from the median, range, and the size of a sample. BMC Medical Research Methodology. ,vol. 5, pp. 13- 13 ,(2005) , 10.1186/1471-2288-5-13
Colin B. Begg, Madhuchhanda Mazumdar, Operating characteristics of a rank correlation test for publication bias. Biometrics. ,vol. 50, pp. 1088- 1101 ,(1994) , 10.2307/2533446
Roberta Ferraldeschi, Laura J Minchell, Stephen A Roberts, Simon Tobi, Kristen D Hadfield, Fiona H Blackhall, Saifee Mullamitha, Gregory Wilson, Juan Valle, Mark Saunders, William G Newman, UGT1A1*28 genotype predicts gastrointestinal toxicity in patients treated with intermediate-dose irinotecan Pharmacogenomics. ,vol. 10, pp. 733- 739 ,(2009) , 10.2217/PGS.09.20
Zhe-Yi Hu, Qi Yu, Yuan-Sheng Zhao, Dose-dependent association between UGT1A1*28 polymorphism and irinotecan-induced diarrhoea: a meta-analysis. European Journal of Cancer. ,vol. 46, pp. 1856- 1865 ,(2010) , 10.1016/J.EJCA.2010.02.049
Donna F Stroup, Jesse A Berlin, Sally C Morton, Ingram Olkin, G David Williamson, Drummond Rennie, David Moher, Betsy J Becker, Theresa Ann Sipe, Stephen B Thacker, Meta-analysis of Observational Studies in EpidemiologyA Proposal for Reporting JAMA. ,vol. 283, pp. 2008- 2012 ,(2000) , 10.1001/JAMA.283.15.2008
Hironobu Minami, Kimie Sai, Mayumi Saeki, Yoshiro Saito, Shogo Ozawa, Kazuhiro Suzuki, Nahoko Kaniwa, Jun-ichi Sawada, Tetsuya Hamaguchi, Noboru Yamamoto, Kuniaki Shirao, Yasuhide Yamada, Hironobu Ohmatsu, Kaoru Kubota, Teruhiko Yoshida, Atsushi Ohtsu, Nagahiro Saijo, Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenetics and Genomics. ,vol. 17, pp. 497- 504 ,(2007) , 10.1097/FPC.0B013E328014341F
F A de Jong, T J Scott-Horton, D L Kroetz, H L McLeod, L E Friberg, R H Mathijssen, J Verweij, S Marsh, A Sparreboom, Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clinical Pharmacology & Therapeutics. ,vol. 81, pp. 42- 49 ,(2007) , 10.1038/SJ.CLPT.6100019
Robert Rosenthal, The file drawer problem and tolerance for null results Psychological Bulletin. ,vol. 86, pp. 638- 641 ,(1979) , 10.1037/0033-2909.86.3.638
Giancarlo A. Pillot, William L. Read, Kristin L. Hennenfent, Sharon Marsh, Feng Gao, Avinash Viswanathan, Kristopher Cummings, Howard L. McLeod, Ramaswamy Govindan, A Phase II Study of Irinotecan and Carboplatin in Advanced Non-small Cell Lung Cancer with Pharmacogenomic Analysis: Final Report Journal of Thoracic Oncology. ,vol. 1, pp. 972- 978 ,(2006) , 10.1016/S1556-0864(15)31629-4
L Iyer, C D King, P F Whitington, M D Green, S K Roy, T R Tephly, B L Coffman, M J Ratain, Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. Journal of Clinical Investigation. ,vol. 101, pp. 847- 854 ,(1998) , 10.1172/JCI915