Development of Pyrosequencing Method for Detection of UGT1A1 Polymorphisms in Thai Colorectal Cancers.
作者： Chonlaphat Sukasem , Chalirmporn Atasilp , Pichai Chansriwong , Montri Chamnanphon , Apichaya Puangpetch
DOI: 10.1002/JCLA.21820
关键词:
摘要: Background UGT1A1 is a polymorphic enzyme that has been associated with irinotecan drug metabolisms. We developed pyrosequencing method to detect allele frequency and genotype of UGT1A1 polymorphisms (UGT1A1*28 UGT1A1*6) in Thai colorectal cancer patients. Method A was designed determine genetic including UGT1A1*28 (A[TA]7TAA) UGT1A1*6 (211G>A) 91 cancers. Result Genotyping by the technique 100% concordant capillary electrophoresis sequencing. The frequencies for were *1/*1 (54.95%), *1/*6 (13.19%), *1/*28 (25.27%), *28/*6 (4.40%), *28/*28 (2.20%). No homozygous mutation found our population. Conclusions We rapid, reliable, more cost-effective, simple assay routine practice before initiating therapy. alleles be similar Asian populations.
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