"Gilbert's-like" syndrome as part of a spectrum of persistent unconjugated hyperbilirubinemia in post-chronic hepatitis patients.

摘要: Gilbert's syndrome (GS) patients present with remittent unconjugated hyperbilirubinemia. In this study, we investigated the correlation between polymorphisms in gene encoding UDP-glucuronosyltransferase, UGT1A1, and development of hyperbilirubinemia clinical GS post-hepatitis Blood samples were collected from 285 patients, including 85 who clinically diagnosed GS, 70 had indirect during recovery period chronic liver diseases, 109 normal hepatic function 21 active hepatitis patients. All tested for presence *28/*6 UGT1A1 genotype by pyrosequencing. Compared GS-control group, a significant difference variations UGT1A1*28/*6 allele was found The group showed frequency distribution relative to that control group. There no differences diplotypes. while recovering diseases presented similar patterns as those seen These findings suggest "Gilbert's-like" might be part spectrum persistent post-chronic