Correlation of UGT1A1*28 and *6 polymorphisms with irinotecan-induced neutropenia in Thai colorectal cancer patients
作者： Chalirmporn Atasilp , Pichai Chansriwong , Ekapob Sirachainan , Thanyanan Reungwetwattana , Montri Chamnanphon
DOI: 10.1016/J.DMPK.2015.12.004
关键词:
摘要: UDP-glucuronosyltransferase1A1 (UGT1A1) polymorphisms have been related with irinotecan toxicity. The purpose of this study was to determine the associations between UGT1A1(*)28 and (*)6 toxicity in Thai patients metastatic colorectal cancer. 44 cancer received irinotecan-based chemotherapy. Hematologic toxicities were determined first second cycles treatment. genotypes analyzed by pyrosequencing technique. frequencies genetic testing for 22.8% (TA6/TA7; 20.5%, TA7/TA7; 2.3%) 15.9% (GA), respectively. No had homozygous UGT1A1(*)6 (AA). Neither nor significantly associated severe hematologic toxicities. However, analysis combination revealed an association neutropenia (P = 0.044, P 0.017, respectively). Both may increased risk irinotecan-induced patients.
sci-hub.se 参考文章(27)
Chonlaphat Sukasem, Chalirmporn Atasilp, Pichai Chansriwong, Montri Chamnanphon, Apichaya Puangpetch, Ekapob Sirachainan, Development of Pyrosequencing Method for Detection of UGT1A1 Polymorphisms in Thai Colorectal Cancers. Journal of Clinical Laboratory Analysis. ,vol. 30, pp. 84- 89 ,(2016) , 10.1002/JCLA.21820
Mark A. Boyd, Preeyaporn Srasuebkul, Kiat Ruxrungtham, Peter I. Mackenzie, Verawan Uchaipichat, Michael Stek, Joep M.A. Lange, Praphan Phanuphak, David A. Cooper, Wandee Udomuksorn, John O. Miners, Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir Pharmacogenetics and Genomics. ,vol. 16, pp. 321- 329 ,(2006) , 10.1097/01.FPC.0000197465.14340.D4
KOICHI HIROSE, CHIHIRO KOZU, KOSHIRO YAMASHITA, EIJI MARUO, MIZUHO KITAMURA, JUNICHI HASEGAWA, KEI OMODA, TERUO MURAKAMI, YORINOBU MAEDA, Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene Oncology Letters. ,vol. 3, pp. 694- 698 ,(2012) , 10.3892/OL.2011.533
Hironobu Minami, Kimie Sai, Mayumi Saeki, Yoshiro Saito, Shogo Ozawa, Kazuhiro Suzuki, Nahoko Kaniwa, Jun-ichi Sawada, Tetsuya Hamaguchi, Noboru Yamamoto, Kuniaki Shirao, Yasuhide Yamada, Hironobu Ohmatsu, Kaoru Kubota, Teruhiko Yoshida, Atsushi Ohtsu, Nagahiro Saijo, Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. Pharmacogenetics and Genomics. ,vol. 17, pp. 497- 504 ,(2007) , 10.1097/FPC.0B013E328014341F
Zhe-Yi Hu, Qi Yu, Qi Pei, Cheng Guo, Dose-Dependent Association between UGT1A1*28 Genotype and Irinotecan-Induced Neutropenia: Low Doses Also Increase Risk Clinical Cancer Research. ,vol. 16, pp. 3832- 3842 ,(2010) , 10.1158/1078-0432.CCR-10-1122
L Iyer, C D King, P F Whitington, M D Green, S K Roy, T R Tephly, B L Coffman, M J Ratain, Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. Journal of Clinical Investigation. ,vol. 101, pp. 847- 854 ,(1998) , 10.1172/JCI915
E Martinez-Balibrea, A Abad, A Martínez-Cardús, A Ginés, M Valladares, M Navarro, E Aranda, E Marcuello, M Benavides, B Massutí, A Carrato, L Layos, J L Manzano, V Moreno, UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy British Journal of Cancer. ,vol. 103, pp. 581- 589 ,(2010) , 10.1038/SJ.BJC.6605776
Kazuhiro Araki, Ken-ichi Fujita, Yuichi Ando, Fumio Nagashima, Wataru Yamamoto, Hisashi Endo, Toshimichi Miya, Keiji Kodama, Masaru Narabayashi, Yasutsuna Sasaki, Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer Cancer Science. ,vol. 97, pp. 1255- 1259 ,(2006) , 10.1111/J.1349-7006.2006.00321.X
Chun-Yu Liu, Po-Min Chen, Tzeon-Jye Chiou, Jin-Hwang Liu, Jen-Kou Lin, Tzu-Chen Lin, Wei-Shone Chen, Jeng-Kae Jiang, Huann-Sheng Wang, Wei-Shu Wang, UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinoma. Cancer. ,vol. 112, pp. 1932- 1940 ,(2008) , 10.1002/CNCR.23370
E Marcuello, A Altés, A Menoyo, E del Rio, M Gómez-Pardo, M Baiget, UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer British Journal of Cancer. ,vol. 91, pp. 678- 682 ,(2004) , 10.1038/SJ.BJC.6602042