Clinically relevant genetic variants of drug-metabolizing enzyme and transporter genes detected in Thai children and adolescents with autism spectrum disorder.

摘要: Single-nucleotide polymorphisms (SNPs) among drug-metabolizing enzymes and transporters (DMETs) influence the pharmacokinetic profile of drugs exhibit intra- interethnic variations in drug response terms efficacy safety profile. The main objective this study was to assess frequency allelic variants absorption, distribution, metabolism, elimination-related genes Thai children adolescents with autism spectrum disorder. Blood samples were drawn from 119 patients, DNA extracted. Genotyping performed using DMET Plus microarray platform. allele frequencies markers generated Console software. Thereafter, genetic significant assessed. SNPs across coding for DMETs determined. After filtering SNPs, 489 1,931 passed quality control. Many clinically relevant including CYP2C19*2, CYP2D6*10, CYP3A5*3, SLCO1B1*5, found have similar those Chinese population. These data are important further research investigate interpatient variability pharmacokinetics pharmacodynamics clinical practice.