Long non-coding RNA polymorphisms and prediction of response to chemotherapy based on irinotecan in patients with metastatic colorectal cancer.

摘要: Background Colorectal cancer is the fourth cause of related death. Drug resistance and toxicity remain major clinical issues. HOTAIR MALAT1 are long non-coding RNAS that affect cellular proliferation, apoptosis drug resistance; their up-regulation has been linked with a poor prognosis. Objective Investigation association between rs4759314 rs3200401 polymorphisms irinotecan-based chemotherapy in terms efficacy toxicity. Methods Samples from 98 patients receiving different regimens therapy were included. Efficacy evaluated. KRAS mutation, genotyping tumors peripheral blood respectively performed PCR. Results Neither nor polymorphism associated response to treatment regimens. Rs4759314 was also not increased CT genotype significantly reduced overall survival. An mutation AG/GG genotypes detected. Conclusions could serve as biomarker. Carriers G allele more likely be carriers mutations too. However, further studies larger patient populations required.