One-pot synthesis of carbazoles from indoles via a metal free benzannulation
作者： Sambasivarao Kotha , Vikas R. Aswar , Ajay Kumar Chinnam
DOI: 10.1016/J.TETLET.2017.10.002
关键词: Organic chemistry 、 Chemistry 、 Moiety 、 Multi-component reaction 、 Metal free 、 Carbazole derivative 、 One-pot synthesis 、 Indole test 、 Diene 、 Diels–Alder reaction
摘要: Abstract We report a simple, one-pot, and metal free benzannulation protocol to carbazoles starting with indoles, carbonyl compounds an appropriate dienophiles. Mechanistically, this strategy generates in situ diene by condensation between indole compound succeed subsequent dehydration. Later, Diels–Alder reaction of suitable dienophile followed oxidation delivers the carbazole derivative. This methodology provide easy access containing 1,4-naphthoquinone moiety.
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