VIP and PACAP Differentially Regulate the Costimulatory Activity of Resting and Activated Macrophages Through the Modulation of B7.1 and B7.2 Expression
作者： Doina Ganea , Javier Leceta , Wei Sun , Mario Delgado
DOI:
关键词: Immune system 、 Endogeny 、 Protein kinase A 、 Biology 、 Endocrinology 、 Vasoactive intestinal peptide 、 Macrophage 、 Neuropeptide 、 Stimulation 、 Internal medicine 、 Receptor
摘要: Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP), two structurally related neuropeptides produced and/or released within the lymphoid microenvironment, modulate numerous immune functions. Although primarily antiinflammatory in nature, VIP PACAP also affect resting macrophages. In this study, we report on vitro vivo dual effects of VIP/PACAP expression B7.1 B7.2 costimulatory activity for T cells unstimulated LPS/IFN-γ-activated up-regulate B7.2, but not B7.1, induce capacity to stimulate proliferation naive response soluble anti-CD3 or allogeneic stimulation. contrast, both down-regulate B7.1/B7.2 macrophages inhibit endotoxin-induced cells. Interestingly, stimulatory inhibitory are mediated through specific receptor VPAC1 involve cAMP/protein kinase A transduction pathway. The effect occurs at mRNA protein level correlates with regulation macrophage activity. Through their regulatory role activated macrophages, act as endogenous participants control homeostasis. Their depend only timing release, activation differentiation state neighboring
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