Prostaglandin E2 Up-Regulates Macrophage-Derived Chemokine Production but Suppresses IFN-Inducible Protein-10 Production by APC

作者: Etsushi Kuroda , Tsutomu Sugiura , Kazumasa Okada , Kazuya Zeki , Uki Yamashita

DOI: 10.4049/JIMMUNOL.166.3.1650

关键词: BiochemistrySpleenImmune systemCXCL16Cell biologyCD40ChemokineCCR4ChemistryCXC chemokine receptorsProstaglandin E2

摘要: PGE(2) has been known to suppress Th1 responses. We studied the role of in two representative chemokines, macrophage-derived chemokine (MDC) and IFN-inducible protein-10, production by LPS- or CD40-stimulated spleen cells. The MDC, one ligands for CCR4 preferentially expressed on Th2, was enhanced nonstimulated, LPS-, CD40-, CD3-stimulated cells pretreatment with PGE(2), while a ligand CXC receptor 3 Th1, suppressed. MDC also IL-4, IL-5, intracellular cAMP-elevating agents such as dibutyryl cAMP 3-isobutyl-1-methylxanthine, effect additive. However, IL-6, IL-10, TGF-beta, neutralization IFN-gamma IL-12 had no production. B cells, macrophages, dendritic were main producers T produced only small amount MDC. equally stimulated LPS anti-CD40 Ab, that macrophages more markedly further these These results indicate regulates Th1/Th2-related this is new function regulation Th2 immune responses at induction activation stages.

参考文章(50)
Albert Zlotnik, Osamu Yoshie, Chemokines: A New Classification System and Their Role in Immunity Immunity. ,vol. 12, pp. 121- 127 ,(2000) , 10.1016/S1074-7613(00)80165-X
Doina Ganea, Javier Leceta, Wei Sun, Mario Delgado, VIP and PACAP Differentially Regulate the Costimulatory Activity of Resting and Activated Macrophages Through the Modulation of B7.1 and B7.2 Expression Journal of Immunology. ,vol. 163, pp. 4213- 4223 ,(1999)
N Shintaku, K Furusho, K Katamura, T Fukui, M Mayumi, Y Ohshima, Y Yamauchi, Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5. Journal of Immunology. ,vol. 155, pp. 4604- 4612 ,(1995)
Marynette Rihanek, Chester G. Elias, Jennifer McNinch, Ming-shi Chang, Scott T. Wathen, Julia Tseng, David P. Andrew, Jason P. Spellberg, STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13. Journal of Immunology. ,vol. 161, pp. 5027- 5038 ,(1998)
E. A. Wierenga, C. M. U. Hilkens, M. L. Kapsenberg, A. Snijders, H. Vermeulen, P. H. Van Der Meide, Accessory cell-derived IL-12 and prostaglandin E2 determine the IFN-gamma level of activated human CD4+ T cells. Journal of Immunology. ,vol. 156, pp. 1722- 1727 ,(1996)
Doina Ganea, Javier Leceta, Rosa P. Gomariz, Mario Delgado, Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide stimulate the induction of Th2 responses by up-regulating B7.2 expression. Journal of Immunology. ,vol. 163, pp. 3629- 3635 ,(1999)
Jon Hanifin, Sai C. Chan, Jin Wou Kim, William R. Henderson, Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis. Journal of Immunology. ,vol. 151, pp. 3345- 3352 ,(1993)
D T Umetsu, R H DeKruyff, C C Goodnow, A E Macaulay, Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4. Journal of Immunology. ,vol. 158, pp. 4171- 4179 ,(1997)
Yoshihiro Ohmori, Wanleng Deng, Thomas A Hamilton, Mechanisms of IL-4-mediated suppression of IP-10 gene expression in murine macrophages. Journal of Immunology. ,vol. 153, pp. 2130- 2136 ,(1994)