Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions

摘要: Sinomenine is one of the alkaloids extracted from Chinese medical plant, Sinomenium acutum Rehder et Wilson. has been used for Rheumatoid arthritis as an anti-infl ammatory and immunomodulative drugs. We have so far investigated cardiovascular pharmacological actions sinomenine. dilated NE (5 μM)-, KCl (60mM)- PDB (300 nM)-induced vasoconstrictions. The pretreatment with nicardipine (0.1 μM), staurosporine (30 nM), L-NMMA (100 indomethacin (10 μM) or propranolol signifi cantly attenuated sinomenine-induced vasorelaxation. Therefore, these results indicate that sinomenine causes vasorelaxation by involvement inhibitions Ca2+ current (ICa) PK-C, β-adrenoceptor stimulation, activation NO PGI2 syntheses in endothelium. On other hand, ventricular cardiomyocytes guinea pig, inhibits ICa simultaneously decreases delayed rectifi er K+ (IK), resulting prolongation action potential duration. also suppresses dysrhysmias induced triggered activities under overload condition. may be expected effective therapeutic drugs heart failure dysrhythmias, maintain functions due to modulation cardiac ionic channels blood vessels.