LC16m8, a Highly Attenuated Vaccinia Virus Vaccine Lacking Expression of the Membrane Protein B5R, Protects Monkeys from Monkeypox

摘要: The potential threat of smallpox as a bioweapon has led to the production and stockpiling vaccine in some countries. Human monkeypox, rare but important viral zoonosis endemic central western Africa, recently emerged United States. Thus, even though been eradicated, vaccinia virus that can induce protective immunity against monkeypox is still invaluable. ability highly attenuated strain LC16m8, with mutation immunogenic membrane protein B5R, nonhuman primates was evaluated comparison parental Lister strain. Monkeys were immunized LC16m8 or then infected intranasally subcutaneously Liberia Zr-599, respectively. Immunized monkeys showed no symptoms intranasal-inoculation model, while nonimmunized controls typical symptoms. In subcutaneous-inoculation except for mild ulcer at site inoculation, those lethal These results indicate prevents monkeys, they suggest may smallpox.