Physical activity and telomere length in U.S. men and women: An NHANES investigation

摘要: The principal objective was to determine the extent which physical activity (PA) accounts for differences in leukocyte telomere length (LTL) a large random sample of U.S. adults. Another purpose assess multiple demographic and lifestyle covariates affect relationship between PA LTL. A total 5823 adults from National Health Nutrition Examination Survey (NHANES 1999-2002) were studied cross-sectionally. Employing quantitative polymerase chain reaction method, LTL compared standard reference DNA. indexed using MET-minutes self-reported frequency, intensity, duration participation 62 activities. Covariates controlled statistically. Telomeres 15.6 base pairs shorter each year chronological age (F=723.2, P<0.0001). inversely related after adjusting all (F=8.3, P=0.0004). Telomere pair with High those Sedentary, Low, Moderate groups 140, 137, 111, respectively. Adults estimated have biologic aging advantage 9years (140 pairs÷15.6) over Sedentary difference cell Low also significant, 8.8years, as (7.1years). Overall, significantly meaningfully associated men women. Evidently, who participate high levels tend longer telomeres, accounting years reduced cellular their more sedentary counterparts.