Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro.
作者： Serap Celikler , Kamel Saleh , Mohammed A.A. Sarhan
DOI: 10.1016/J.SJBS.2010.04.004
关键词: Thiocyclam 、 Chromosome 、 Chromosome aberration 、 Metaphase 、 Biology 、 Immunology 、 Genotoxicity 、 Molecular biology 、 Mitotic index 、 Cell growth 、 In vitro
摘要: Thiocyclam (trade name Evisect) is a broad-spectrum nereistoxin analogue insecticide used widely for agricultural applications. The aim of this investigation was to determine its genotoxic effects in the chromosome aberration (CA) test and determining mitotic index (MI), using lymphocytes from peripheral blood samples healthy human donors. A negative positive control (MMC) were also included. Chromosomal analyses metaphase plates treated with 14 different concentrations (from 0.1 120 μg/ml) thiocyclam, indicating lack effect on chromosomes. Thus thiocyclam not but highly toxic cell proliferation lymphocytes.
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