Effects of amantadine hydrochloride on catecholamine metabolism in the brain of the rat.

摘要: Abstract We have examined the effects of cyclic amine, amantadine, on metabolism catecholamines in rat. Large doses drug had minimal cardiac norepinephrine stores, but produced small decreases concentrations brain, while having less effect dopamine and no serotonin. The altered previously intrathecally administered [ 3 H]norepinephrine: there were H]norepinephrine, clear H]deaminated catechol metabolites marked increases H]normetanephrine for 1–6 hr, at times paralleling endogenous levels. Later, smaller H ] deaminated -O- methylated products appeared. These metabolic changes not due to inhibition monoamine oxidase by this drug, as amantadine deamination 14 C]serotonin or H]norepinephrine even high vitro vivo . Amantadine decreased retention isolated nerve endings injected a very amount competitively inhibited initial uptake ]d,l- whole with K i approximately 1.5 × 10 −5 M. This was somewhat greater cerebral cortex than corpus striatum. There much H]dopamine both regions. Thus, part action Parkinson's disease may be central terminals. However, since required produce higher those used clinically, these findings reflect non-specific toxic drug.