Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
作者： O. A. Ibrahimi , A. V. Eliseenkova , A. N. Plotnikov , K. Yu , D. M. Ornitz
关键词: Autocrine signalling 、 Paracrine signalling 、 Apert syndrome 、 Biology 、 Mutation 、 Fibroblast growth factor receptor 2 、 Molecular biology 、 Fibroblast growth factor receptor 3 、 Point mutation 、 Fibroblast growth factor
摘要: … FGFR2(IIIc) to bind mesenchymally expressed FGF7 and FGF10. Because of loss of FGFR2(IIIc)-binding … result from inappropriate autocrine activation of FGFR2(IIIc). Moreover, …
rcsb.org
core.ac.uk
harvard.edu参考文章(34)
T. A. Jones, J. Y. Zou, S. W. Cowan, M. Kjeldgaard, Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallographica Section A. ,vol. 47, pp. 110- 119 ,(1991) , 10.1107/S0108767390010224
Joy M. Richman, Maxine Herbert, Elizabeth Matovinovic, Joanne Walin, EFFECT OF FIBROBLAST GROWTH FACTORS ON OUTGROWTH OF FACIAL MESENCHYME Developmental Biology. ,vol. 189, pp. 135- 147 ,(1997) , 10.1006/DBIO.1997.8656
K. Yu, A. B. Herr, G. Waksman, D. M. Ornitz, Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 14536- 14541 ,(2000) , 10.1073/PNAS.97.26.14536
P. J. Kraulis, MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures Journal of Applied Crystallography. ,vol. 24, pp. 946- 950 ,(1991) , 10.1107/S0021889891004399
Joseph Schlessinger, Alexander N. Plotnikov, Omar A. Ibrahimi, Anna V. Eliseenkova, Brian K. Yeh, Avner Yayon, Robert J. Linhardt, Moosa Mohammadi, Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization Molecular Cell. ,vol. 6, pp. 743- 750 ,(2000) , 10.1016/S1097-2765(00)00073-3
Michael Oldridge, Elaine H. Zackai, Donna M. McDonald-McGinn, Sachiko Iseki, Gillian M. Morriss-Kay, Stephen R.F. Twigg, David Johnson, Steven A. Wall, Wen Jiang, Christiane Theda, Ethylin Wang Jabs, Andrew O.M. Wilkie, De novo alu-element insertions in FGFR2 identify a distinct pathological basis for Apert syndrome. American Journal of Human Genetics. ,vol. 64, pp. 446- 461 ,(1999) , 10.1086/302245
D. J. Stauber, A. D. DiGabriele, W. A. Hendrickson, Structural interactions of fibroblast growth factor receptor with its ligands Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 49- 54 ,(2000) , 10.1073/PNAS.97.1.49
G. Venkataraman, R. Raman, V. Sasisekharan, R. Sasisekharan, MOLECULAR CHARACTERISTICS OF FIBROBLAST GROWTH FACTOR-FIBROBLAST GROWTH FACTOR RECEPTOR-HEPARIN-LIKE GLYCOSAMINOGLYCAN COMPLEX Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 3658- 3663 ,(1999) , 10.1073/PNAS.96.7.3658
Salem Faham, Robert J Linhardt, Douglas C Rees, Diversity does make a difference: fibroblast growth factor-heparin interactions. Current Opinion in Structural Biology. ,vol. 8, pp. 578- 586 ,(1998) , 10.1016/S0959-440X(98)80147-4
Andrew O.M. Wilkie, Sarah F. Slaney, Michael Oldridge, Michael D. Poole, Geraldine J. Ashworth, Anthony D. Hockley, Richard D. Hayward, David J. David, Louise J. Pulleyn, Paul Rutland, Susan Malcolm, Robin M. Winter, William Reardon, Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome. Nature Genetics. ,vol. 9, pp. 165- 172 ,(1995) , 10.1038/NG0295-165