Diversity does make a difference: fibroblast growth factor-heparin interactions.
作者： Salem Faham , Robert J Linhardt , Douglas C Rees
DOI: 10.1016/S0959-440X(98)80147-4
关键词:
摘要: Fibroblast growth factors (FGFs) are members of a protein family with broad range biological activities. The best characterized FGFs interact two distinct extracellular receptors — transmembrane tyrosine kinase FGF receptor (FGFR) and heparan sulfate-related proteoglycan the matrix. These components form FGF—FGFR—proteoglycan complex that activates FGF-mediated signal transduction process through FGFR dimerization. Recent crystal structure determinations FGF—heparin complexes have provided insights into both interactions between these role heparin-like proteoglycans in function. Future advances this field will benefit enormously from an ability to specifically prepare homogenous heparin-based oligosaccharides defined sequence for use biochemical structural studies many other systems.
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