Continuous hypertonic saline therapy and the occurrence of complications in neurocritically ill patients*

摘要: Objective: To evaluate potential side effects of continuous hypertonic 3% saline (CHS) as maintenance fluid in patients with brain injury. Methods: Retrospective chart analysis prospectively collected data. Patients: Patients admitted to the neurosurgical intensive care unit for >4 days traumatic injury, stroke, or subarachnoid hemorrhage a Glasgow Coma Scale 155 mmol/L) and severe hypernatremia (Na >160 was significantly higher CHS therapy group than NS group. No significant relationship between infusion renal dysfunction found. Moderate associated risk elevated blood urea nitrogen creatinine levels. Acute failure not seen these patients. A total 53.3% 16.3% (p 25 mm Hg), consistent physicians decision use ICP. Conclusions: an increased rate infection, deep vein thrombosis, failure. However, there developing hypernatremia. We conclude that administration injuries is safe long sodium levels are carefully monitored. (Crit Care Med 2009; 37:1433‐1441)