A toxic self-made beverage: Analytics of alkaloids from Veratrum album by LC-MS/MS

作者: H. Müller , T. Grobosch , T. Binscheck , D. Lampe , F. Martens

DOI:

关键词: VeratrumActivated charcoalNauseaIngestionAnesthesiaBradycardiaYellow GentianVomitingProtoveratrinesMedicine

摘要: A 49-year-old man consumed two glasses (approx. 2 x 20 ml) of a beverage containing yellow gentian (Gentiana lutea). Shortly after ingestion, he developed nausea, vomiting and oral paraesthesia. On admission to the hospital suffered from severe bradycardia hypotension was treated with activated charcoal, antiemetics, atropine i.v. volume. The patient completely recovered symptoms within 24 hours discharged hospital. initial suspicion Veratrum poisoning confirmed by identifying protoveratrines (ProA) protoveratrine B (ProB) in sample as well patients serum LC-(ESI)-MS-MS.

参考文章(13)
Bernhard Zagler, Anton Zelger, Carmen Salvatore, Christoph Pechlaner, Franco De Giorgi, Christian J. Wiedermann, Dietary poisoning with Veratrum album--a report of two cases. Wiener Klinische Wochenschrift. ,vol. 117, pp. 106- 108 ,(2005) , 10.1007/S00508-004-0291-X
John R. Baker, Enzyklopadie der psychoaktiven Pflanzen:Enzyklopadie der psychoaktiven Pflanzen. American Anthropologist. ,vol. 101, pp. 688- 689 ,(1999) , 10.1525/AA.1999.101.3.688
Joseph Levine, Henry Fischbach, Determination of Protoveratrine II.*: Separation of Protoveratrines A and B from Associated Alkaloids Journal of the American Pharmaceutical Association. ,vol. 46, pp. 191- 192 ,(1957) , 10.1002/JPS.3030460314
Hui-liang Li, Jian Tang, Run-hui Liu, Min Lin, Bin Wang, Yi-feng Lv, Hai-qiang Huang, Chuan Zhang, Wei-dong Zhang, Characterization and identification of steroidal alkaloids in the Chinese herb Veratrum nigrum L. by high‐performance liquid chromatography/electrospray ionization with multi‐stage mass spectrometry Rapid Communications in Mass Spectrometry. ,vol. 21, pp. 869- 879 ,(2007) , 10.1002/RCM.2909
G. Quatrehomme, F. Bertrand, C. Chauvet, A. Ollier, Intoxication from Veratrum album Human & Experimental Toxicology. ,vol. 12, pp. 111- 115 ,(1993) , 10.1177/096032719301200203
Xuejun Zang, Elaine K. Fukuda, Joseph D. Rosen, Method for the Determination of Veratridine and Cevadine, Major Components of the Natural Insecticide Sabadilla, in Lettuce and Cucumbers Journal of Agricultural and Food Chemistry. ,vol. 45, pp. 1758- 1761 ,(1997) , 10.1021/JF9606013
J. Daniel Hare, Purification and quantitative analysis of veratridine and cevadine by HPLC Journal of Agricultural and Food Chemistry. ,vol. 44, pp. 149- 152 ,(1996) , 10.1021/JF9406828
Y. Gaillard, G. Pepin, LC-EI-MS Determination of Veratridine and Cevadine in Two Fatal Cases of Veratrum album Poisoning Journal of Analytical Toxicology. ,vol. 25, pp. 481- 485 ,(2001) , 10.1093/JAT/25.6.481
M Guirguis-Oeschger, R Jaspersen-Schib, L Theus, P J Meier-Abt, B Gossweiler, [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweizerische Medizinische Wochenschrift. ,vol. 126, pp. 1085- 1098 ,(1996)
S. Morris. Kupchan, Norbert. Gruenfeld, N. Katsui, Veratrum Alkaloids. XLIX.1The Structures and Configurations of Sabine and Sabadine2,3 Journal of Medicinal and Pharmaceutical Chemistry. ,vol. 5, pp. 690- 714 ,(1962) , 10.1021/JM01239A002