Flow-Induced Damage to Blood Cells in Aortic Valve Stenosis

摘要: Valvular hemolysis and thrombosis are common complications associated with stenotic heart valves. This study aims to determine the extent which hemodynamics induce such traumatic events. The viscous shear stress downstream of a severely calcified bioprosthetic valve was evaluated via in vitro 2D particle image velocimetry measurements. blood cell membrane response measured stresses then quantified using 3D immersed-boundary computational simulations. level at boundary layer jet flow formed orifice observed reach maximum 1000–1700 dyn/cm2, beyond threshold values reported for platelet activation (100–1000 dyn/cm2) within range thresholds red (RBC) damage (1000–2000 dyn/cm2). Computational simulations demonstrated that resultant tensions RBC surface were unlikely cause instant rupture, but likely lead plastic failure. also calculated potential discussed. It concluded although shear-induced thrombotic trauma is very valves, RBCs mostly subhemolytic.