Normal FGF23 Levels in Adult Idiopathic Phosphate Diabetes
作者： M. Laroche , J. F. Boyer , H. Jahafar , J. Allard , I. Tack
DOI: 10.1007/S00223-008-9204-8
关键词: Osteoporosis 、 Bone disease 、 Osteopenia 、 Phosphate 、 Endocrinology 、 Parathyroid hormone 、 Internal medicine 、 Medicine 、 Calcium 、 Reabsorption 、 Fibroblast growth factor 23
摘要: Fibroblast growth factor 23 (FGF23), a recently discovered phosphaturic substance playing key role in genetic and oncogenic phosphate diabetes, is involved the physiological regulation of metabolism. Moderate idiopathic diabetes (IPD) leading to male osteoporosis diffuse pain resembling fibromyalgia has been described. The aim our study was define FGF23 mechanism IPD. concerned 29 patients with IPD, mean age 53 ± 11 years, whom 72% were men. Fifteen subjects without bone disease normal serum calcium levels used as controls. Phosphate confirmed by reabsorption level <85% threshold (TmPO4/GFR) <0.83. Known causes excluded. Fasting FGF23, phosphate, 1-25(OH)2D3, parathyroid hormone measured compared healthy Spinal hip mineral density (BMD) osteodensitometry. Sixteen had pain, 10 according World Health Organization criteria, 11 osteopenia. Serum significantly lower than controls, but did not differ. Compared status, osteopenia decreased levels, whereas identical two groups. In all patients, positively correlated 1-25(OH)2D3 negatively correlated. seems be cause FGF23/phosphate/1-25(OH)2D3 axis appeared functional.
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