Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy

摘要: Abnormal kidney function is common in the course of human immunodeficiency virus (HIV) infection. Here, we performed a cross-sectional analysis using 399 patients within Aquitaine cohort (a hospital-based HIV-1-infected receiving routine clinical management) to estimate prevalence proximal renal tubular dysfunction (PRTD) associated with HIV These did not differ statistically by sociodemographics, median age, years since diagnosis, AIDS stage, or CD4 cell count from entire 3080 patient cohort. Antiretroviral therapy was received 352 patients, 256 given tenofovir (TDF); 325 had undetectable plasma viral load, and 26 were diagnosed PRTD. In multivariate analysis, significant independent associations found between PRTD age (odds ratio (OR) 1.28 per 5-year increase), atazanavir (OR year exposure), TDF 1.23 year) treatment. Among having TDF-containing regimens over period, remained significantly exposure when treatment ongoing 5.22) been discontinued 11.49). Thus, cumulative and/or an increased risk PRTD, concern about its reversibility HIV.