Antenatal causes of cerebral palsy: associations between inherited thrombophilias, viral and bacterial infection, and inherited susceptibility to infection.

作者: Catherine S. Gibson , Alastair H. MacLennan , Paul N. Goldwater , Gustaaf A. Dekker

DOI: 10.1097/01.OGX.0000055205.21611.6E

关键词: ObstetricsFetusChorioamnionitisPregnancyCerebral palsyLow birth weightNeuropathologyEpidemiologyThrombophiliaMedicine

摘要: UNLABELLED Cerebral palsy rates of 2 in every 1,000 births have varied little over the last 40 years, despite improvements obstetric care. In past, cerebral was thought to be due poor care and management; however, epidemiological studies refuted this, suggesting that there is usually an antenatal timing neuropathology palsy. There are many known risk factors for palsy, including multiple gestation, prematurity, low birth weight. Recently, intrauterine infection, maternal pyrexia, presence thrombophilic disorders (thrombophilia) been identified as major subsequent This review examines links between fetal inflammatory response, thrombophilia possible causes The interactions viral or bacterial infections during pregnancy, normal abnormal cytokine responses, hereditary thrombophilias now areas research priority. TARGET AUDIENCE Obstetricians & Gynecologists, Family Physicians LEARNING OBJECTIVES After completion this article, reader will able describe condition list development outline ultrasound findings associated with point out other conditions

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