Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

摘要: OBJECTIVE: Periventricular leukomalacia, a common brain white matter lesion in preterm neonates, is major risk factor for cerebral palsy. Recently, cytokines (i.e., tumor necrosis and interleukin-1β) have been implicated as mediators the development of periventricular leukomalacia. The purpose this study was to examine relationship between umbilical cord plasma levels factor-α, interleukin-1β, interleukin-6, interleukin-1 receptor antagonist occurrence leukomalacia neonates. STUDY DESIGN: Umbilical blood collected from 172 consecutive births (25 36 weeks). - associated lesions were diagnosed by ultrasonography within first 3 days life. Tumor measured sensitive specific enzyme-linked immunoassay methods. arterial pH at birth. Statistical analysis performed with multiple logistic regression receiver operating characteristic curve analysis. RESULTS: leukomalacia–associated present 14.5% (25/172) infants. Plasma concentrations interleukin-6 but not significantly higher neonates than those without these (median 718, range <226 32,000 pg/ml vs median <226, 43,670 pg/ml; p < 0.0001). An value ≥400 had sensitivity 72% (18/25) specificity 74% (108/147) identification lesions. Multivariate showed that an independent (odds ratio 6.2, 0.002) after correction known confounding variables gestational age birth, artery pH, chorioamnionitis). CONCLUSIONS: Interleukin-6 are elevated Our data support hypothesis may be result cytokine-mediated injury. (AM J OBSTET GYNECOL 1996;174:1433-40.)