Diffusion MRI Brain Findings in Neonates Exposed to Chorioamnionitis: A Case Series

摘要: Abstract Objective The primary objective of this study was to determine the feasibility using diffusion-weighted magnetic resonance imaging (DWMRI) assess white matter changes in high-risk neonates. Secondary objectives were if exposure chorioamnionitis (clinical or histopathologic) is associated with DWMRI findings neonatal brain, and calculate sample size required for a more definitive prospective cohort study. Methods Seventeen women PPROM (preterm premature rupture membranes) who delivered 18 infants not requiring ventilatory support recruited participate case series. When stable, underwent scanning. All placentas examined evidence histopathologic (HCA). Results There seven examined; three these patients had clinical chorioamnionitis. Diffusion MRI revealed both apparent diffusion coefficient confirmed have HCA (43%), while only one 11 normal (9%) showed similar findings. Routine head ultrasound examination demonstrated abnormal cortical that would normally prompt further investigation infants. Conclusion Exposure may be on brain within 96 hours delivery. Further delineate association long-term neurodevelopmental sequelae.