Synthesis of Aminobenzoic Acid Derivatives via Chemoselective Carbene Insertion into the −NH Bond Catalyzed by Cu(I) Complex
作者： Kankanala Ramakrishna , Chinnappan Sivasankar
关键词: Chemistry 、 Aminobenzoic acid 、 Reaction conditions 、 Organic chemistry 、 Carbene 、 Polymer chemistry 、 Phosphine 、 Ligand 、 Catalysis
摘要: Phosphine ligand stabilized air-stable Cu(I) complexes have been successfully used to functionalize the aromatic aminobenzoic acids in a chemoselective manner without implementing protection and deprotection strategy under mild reaction conditions. This carbene insertion into −NH bond over −COOH −OH bonds leads wide range of carboxy hydroxy functionalized α-amino esters (27 examples). All isolated new products fully characterized using standard analytical methods.
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