Is ascorbic acid an antioxidant for the plasma membrane
作者： James M. May
关键词: Chemistry 、 Membrane 、 Ascorbic acid 、 Ferricyanide 、 Biophysics 、 Membrane lipids 、 Dehydroascorbic acid 、 Antioxidant 、 Electron transport chain 、 Oxidoreductase
摘要: Ascorbic acid, or vitamin C, is a primary antioxidant in plasma and within cells, but it can also interact with the membrane by donating electrons to α-tocopheroxyl radical trans-plasma oxidoreductase activity. Ascorbate-derived reducing capacity thus transmitted both into across membrane. Recycling of α-tocopherol ascorbate helps protect lipids from peroxidation. However, neither mechanism nor function ascorbate-dependent activity known. This has typically been studied using extracellular ferricyanide as an electron acceptor. Whereas NADH:ferricyanide reductase evident open membranes, preferred donor cells. The may be single membrane-spanning protein only partially span part trans-membrane transport chain composed cytochrome even hydrophobic antioxidants such ubiquinol-10. Furthe...
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