Cord blood transplantation and stem cell regenerative potential.

摘要: The past 20 years of experience with umbilical cord blood transplantation have demonstrated that is effective in the treatment a spectrum diseases, including hematological malignancies, bone marrow failure, hemoglobinopathies, and inborn errors metabolism. Cord can be obtained ease then safely cryopreserved for either public or private use without loss viability. As compared to other unrelated donor cell sources, allows greater human leukocyte antigen disparity corresponding increase graft-vs.-host disease. Moreover, has lower risk transmitting infections by latent viruses less likely carry somatic mutations than adult cells. Recently, multiple populations stem cells primitive properties been identified from blood. Meanwhile, there an increasing interest applying mononuclear enriched regenerative therapies. Accumulating evidence suggested functional improvements after various animal models treatments cardiac infarction, diabetes, neurological etc. In this review, we will summarize most recent updates on clinical applications promises limitations cell-based therapies tissue repair regeneration.