Assessment of bagging GBLUP for whole‐genome prediction of broiler chicken traits

作者: R. Abdollahi-Arpanahi , G. Morota , B.D. Valente , A. Kranis , G.J.M. Rosa

DOI: 10.1111/JBG.12131

关键词: MathematicsGenomeBioinformaticsVariance reductionCorrelationBest linear unbiased predictionStatisticsBroilerSample size determinationBootstrap aggregatingResampling

摘要: Summary Bootstrap aggregation (bagging) is a resampling method known to produce more accurate predictions when predictors are unstable or the number of markers much larger than sample size, because variance reduction capabilities. The purpose this study was compare genomic best linear unbiased prediction (GBLUP) with bootstrap aggregated sampling GBLUP (Bagged GBLUP, BGBLUP) in terms accuracy. We used 600 K Affymetrix platform 1351 birds genotyped and phenotyped for three traits broiler chickens; body weight, ultrasound measurement breast muscle hen house egg production. predictive performance versus BGBLUP evaluated different scenarios consisting including excluding TOP 20 from standard genome-wide association (GWAS) as fixed effects model, varying training sizes allelic frequency bins. Predictive assessed via five replications threefold cross-validation using correlation between observed predicted values, mean-squared error. overfitted set data, delivered better ability testing sets. Treating GWAS into model improved accuracy added advantages over GBLUP. at allele bins similar. In general, results confirm that can be valuable enhancing genome-enabled complex traits.

参考文章(24)
C. R. Henderson, Comparison of Alternative Sire Evaluation Methods Journal of Animal Science. ,vol. 41, pp. 760- 770 ,(1975) , 10.2527/JAS1975.413760X
A Nejati-Javaremi, C Smith, J P Gibson, Effect of Total Allelic Relationship on Accuracy of Evaluation and Response to Selection Journal of Animal Science. ,vol. 75, pp. 1738- 1745 ,(1997) , 10.2527/1997.7571738X
Andrew E Jaffe, John D Storey, Hongkai Ji, Jeffrey T Leek, Gene set bagging for estimating the probability a statistically significant result will replicate BMC Bioinformatics. ,vol. 14, pp. 360- 360 ,(2013) , 10.1186/1471-2105-14-360
Carlos Valle, Ricardo Ñanculef, Héctor Allende, Claudio Moraga, Two bagging algorithms with coupled learners to encourage diversity intelligent data analysis. pp. 130- 139 ,(2007) , 10.1007/978-3-540-74825-0_12
T. H. E. Meuwissen, M. E. Goddard, B. J. Hayes, Prediction of Total Genetic Value Using Genome-Wide Dense Marker Maps Genetics. ,vol. 157, pp. 1819- 1829 ,(2001) , 10.1093/GENETICS/157.4.1819
Daniel Gianola, Kent A. Weigel, Nicole Krämer, Alessandra Stella, Chris-Carolin Schön, Enhancing genome-enabled prediction by bagging genomic BLUP. PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0091693
Xiao-Lin Wu, Timothy M. Beissinger, Stewart Bauck, Brent Woodward, Guilherme J. M. Rosa, Kent A. Weigel, Natalia de Leon Gatti, Daniel Gianola, A primer on high-throughput computing for genomic selection. Frontiers in Genetics. ,vol. 2, pp. 4- 4 ,(2011) , 10.3389/FGENE.2011.00004
Li Chen, Jianhua Xuan, Rebecca B. Riggins, Yue Wang, Robert Clarke, Identifying protein interaction subnetworks by a bagging Markov random field-based method Nucleic Acids Research. ,vol. 41, ,(2013) , 10.1093/NAR/GKS951
Ricardo de Matos Simoes, Frank Emmert-Streib, Bagging Statistical Network Inference from Large-Scale Gene Expression Data PLOS ONE. ,vol. 7, pp. 1- 11 ,(2012) , 10.1371/JOURNAL.PONE.0033624