Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
作者： Randolph S Watnick , Yi-Ning Cheng , Annapoorni Rangarajan , Tan A Ince , Robert A Weinberg
DOI: 10.1016/S1535-6108(03)00030-8
关键词: Regulation of gene expression 、 Psychological repression 、 Biology 、 Immunology 、 Cell biology 、 Signal transduction 、 Vascular endothelial growth factor A 、 Kinase 、 Phosphorylation 、 Angiogenesis 、 Thrombospondin 1
摘要: Tumor angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate that critical step in establishing angiogenic capability of human cells repression factor, thrombospondin-1 (Tsp-1). This essential for tumor formation mammary epithelial kidney engineered express SV40 early region proteins, hTERT, H-RasV12. have uncovered signaling pathway leading from Ras Tsp-1 repression. induces sequential activation PI3 kinase, Rho, ROCK, Myc through phosphorylation; phosphorylation via this mechanism enables it repress expression. thus describe a novel which cooperative activity oncogenes, ras myc, leads directly formation.
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