Clinical profile of PiB-positive corticobasal syndrome.

摘要: Background: Corticobasal syndrome (CBS) is a multifaceted neurodegenerative disorder characterized by combination of motor and cognitive deficits. Several different pathological entities, including Alzheimer's pathology, have been described in association with CBS. The present study aimed to establish clinical, neuropsychological, neuroimaging features that could be useful the distinction CBS due AD pathology from other cases life based on [11C] Pittsburgh Compound B positron emission tomography (PiB-PET) status. Methods: Patients were prospectively recruited specialized disorders clinic. All patients underwent detailed clinical neuropsychological assessment, structural imaging using voxel-based analysis magnetic resonance imaging. was detected PiB-PET imaging, PiB-positive PiB-negative groups compared. Results: Fourteen meeting defined criteria included (7 male, 7 female; mean age 66.1+/-6.9 years; median symptom duration 35.5+/-22.6 months) compared 20 matched control subjects. Of 14 patients, 4 10 PiB-negative. There no significant differences between age, gender, education, duration, or features. had greater visuospatial deficits, higher rate sentence repetition impairment, more functional decline. Voxel-based morphometry analyses demonstrated extensive peri-insular post-central atrophy both groups, but extended include posterior part left superior temporal gyrus. Conclusions: Visuospatial function, aspects language, pattern cerebral may distinguishing underlying pathology.